Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) <doi:10.1101/gr.262675.120> and Chen et al. (2022) <doi:10.1186/s13059-022-02627-9> for associated statistical details.
Version: 1.2.2 Depends: R (≥ 3.5.0) Imports: stats, graphics, methods, locfit (≥ 1.5.9), scales (≥ 0.3.0), statmod (≥ 1.4.34) Suggests: gplots (≥ 3.0.1), DescTools (≥ 0.99.24), knitr, rmarkdown Published: 2022-10-28 DOI: 10.32614/CRAN.package.MAnorm2 Author: Shiqi Tu [aut, cre] Maintainer: Shiqi Tu <tushiqi at picb.ac.cn> BugReports: https://github.com/tushiqi/MAnorm2/issues License: GPL-3 URL: https://github.com/tushiqi/MAnorm2 NeedsCompilation: no Citation: MAnorm2 citation info Materials: README, NEWS CRAN checks: MAnorm2 results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=MAnorm2 to link to this page.
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