A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.
Version: 1.0.1 Depends: R (≥ 3.6) Imports: nlme, RLRsim, stats Suggests: rmarkdown, knitr Published: 2021-12-10 DOI: 10.32614/CRAN.package.GEVACO Author: Zhengyang Zhou [aut] Sydney Manning [aut, cre] Chao Xing [aut] Hung-Chih Ku [aut] Maintainer: Sydney Manning <sydney.manning at unthsc.edu> License: GPL-3 NeedsCompilation: no CRAN checks: GEVACO results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=GEVACO to link to this page.
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