Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.
Version: 1.5 Imports: Rcpp (≥ 0.12.18), mvtnorm LinkingTo: Rcpp, RcppArmadillo Published: 2020-07-31 DOI: 10.32614/CRAN.package.Phase12Compare Author: Andrew G Chapple Maintainer: Andrew G Chapple <achapp at lsuhsc.edu> License: GPL-2 NeedsCompilation: yes CRAN checks: Phase12Compare results Documentation: Reference manual: Phase12Compare.pdf Downloads: Package source: Phase12Compare_1.5.tar.gz Windows binaries: r-devel: Phase12Compare_1.5.zip, r-release: Phase12Compare_1.5.zip, r-oldrel: Phase12Compare_1.5.zip macOS binaries: r-release (arm64): Phase12Compare_1.5.tgz, r-oldrel (arm64): Phase12Compare_1.5.tgz, r-release (x86_64): Phase12Compare_1.5.tgz, r-oldrel (x86_64): Phase12Compare_1.5.tgz Old sources: Phase12Compare archive Linking:Please use the canonical form https://CRAN.R-project.org/package=Phase12Compare to link to this page.
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