It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) <doi:10.1016/j.envres.2022.112890> and Feng et al. (2022) <doi:10.7150/ijms.67815> for disease expression profiles; see Wishart et al. (2018) <doi:10.1093/nar/gkx1037> and Gaulton et al. (2017) <doi:10.1093/nar/gkw1074> for drug target information; see Kanehisa et al. (2021) <doi:10.1093/nar/gkaa970> for the details of KEGG database.)
Version: 0.0.3 Depends: R (≥ 4.0.0) Imports: dplyr, fgsea, igraph, magrittr, tibble, tidyr, BiocParallel, stringr Suggests: knitr, rmarkdown Published: 2022-11-06 DOI: 10.32614/CRAN.package.DTSEA Author: Junwei Han [aut, cre, cph], Yinchun Su [aut] Maintainer: Junwei Han <hanjunwei1981 at 163.com> License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] NeedsCompilation: no Materials: README NEWS CRAN checks: DTSEA results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=DTSEA to link to this page.
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